NEW! Osteoallograft now available for Equines! To see information about Osteoallograft Orthomix for equine orthopedics, please click here (PDF: 594 KB) To see information about Osteoallograft Periomix for equine periodontics, please click here (PDF: 694 KB)
Get
strong and fast biologic healing through osteoinduction. Having
both osteoconductive and osteoinductive properties, Osteoallograft™
provides the full spectrum of factors needed to promote bone healing.
It is used in void filling (TTA, TPLO, bone loss), fracture repair, spinal
fusions, arthrodeses, periodontics and more.
Osteoallograft is natural, species-specific bone allograft for dogs and cats. It consists of osteoconductive cancellous bone chips and osteoinductive demineralized bone matrix (DBM). There are no other carrier additives to dilute the volume of bone delivered to the surgical site. All tissue grafts are collected aseptically and processed in a sterile, laminar airflow environment. The cancellous bone graft is produced by creating small chips from the cancellous compartment in bone. The DBM consists of cortical bone that has been ground to particle sizes of 1.25 mm or less and demineralized. The demineralization procedure utilizes methods that have been shown to leave the matrix and endogenous bone growth factors in place. Grafts are conveniently packaged for individual case management.
Osteoallogaft™ Orthomix™ is used in orthopedic cases. Orthomix - Standard has chip sizes of 4 mm and smaller, Orthomix - Fine has chip sizes of 2.5 mm and smaller. Cancellous bone chips and DBM are also available individually.
Osteoallograft™ Periomix™ is used in periodontic applications. Periomix contains cancellous chips that have been sieved to smaller than 0.7 mm.
Advantages
As effective
as autograft in long term outcomes.
Completely
natural biological repair – fuses with, and
eventually replaced by, the recipient’s own
bone.
Reduces
OR time and is cost effective.
Reduces
patient pain and other morbidity (no need to obtain
autograft).
Cancellous
Chips provide scaffolding that facilitates migration
of osteoblasts.
Demineralization
exposes the native bone growth factors in the matrix
so they are immediately available when implanted
(bypasses resorption as the first step in bone healing).
Staged
plate removal in osteopenic or geriatric patients
Spinal
fusions, arthrodeses, periodontics, etc.
Use
wherever bone graft is needed
Composition
Cancellous
Chips are osteoconductive. They are (approximately 4mm in size and are made from
the cancellous compartment in bone. They have been
purged of the cellular and lipid elements in marrow
to reduce immunogenicity, treated with antibiotics,
and rinsed prior to packaging (available as frozen
only).
Demineralized
Bone Matrix (DBM) is osteoinductive. It is made from cortical bone that
has been ground to particle sizes of 1.25 mm or
less. The mineral content is reduced using hydrochloric
acid. This leaves the matrix and the acid-resistant,
endogenous bone growth factors in place (available
as frozen only).
Orthomix - Standard is a mix of DBM and has cancellous chips that are large (sieved to <4 mm). Ideal for fracture repair or any type of void filling where larger cancellous bone chips are needed (available as frozen or freeze-dried).
Orthomix - Fine is a mix of DBM and cancellous chips that have been sieved to < 2.5 mm chip size. It is designed to facilitate packing into small spaces, for example in arthrodeses, smaller fracture gaps, or staged plate removals (available as frozen or freeze-dried).
Periomix is a mix of DBM and cancellous chips that are < 0.7 mm in size. This makes it ideal for periodontic applications such as tooth extractions, furcation defects, horizontal and vertical bone loss, or fracture of the mandible (available as freeze-dried only)
Storage
Frozen
grafts should be kept frozen (at least
at -20°C) until ready for use. If stored at
-20°C (or in a standard household freezer),
they should be used within 6 months of receipt.
If stored at -40°C or colder, the grafts can
be stored for 5 years.
Freeze-dried
grafts can be stored refrigerated or at
room temperature for 5 years from the date of packaging.
A Package Insert (with Transplant Record) is enclosed
with each graft; it contains instructions for handling
and use.